Three other dogs required frequent catheterisation and antibiotics were administered. The side-effect of prazosin, as with other alpha-blockers, is hypotension (4,9). The objective of treatment is to relax the urethra without blocking the contraction of the detrusor muscle. ... Detrusor atony Clinical signs ... pathophysiology and medical treatment. 4. However, if this occurs, longer hospitalization is necessary. Only two patients became depressed and in them the dose was reduced by 50%. months (mean 21 mo)… in 43% of dogs. 186: 18 – 24. Another three dogs …

There was a good effect in seven and a moderate response in the other four dogs. The dosage for dogs or cats is 0.25 mg/kg, PO, bid. Noel S, Claeys S, Hamaide A. Although its action is dose-dependent, a decreased response is observed after administration of high dosages because of receptor desensitisation and calcium depletion ( Buranakarl et al., 2001 ). Part 2: The urethral component, pathophysiology and medical treatment. 186: 10 – 17. Further Reading Publications Refereed papers. Detrusor-Striated Sphincter Dyssynergia in a Dog Jody L. Gookin and Susan E. Bunch A 7-year-old neutered male Cocker Spaniel was admitted for evaluation of urinary incontinence; 16 months earlier, the dog had been examined by the referring veterinarian because of signs of priapism, urine dribbling, and recurrent antibiotic-responsive hema- turia and pollakiuria. Phenoxybenzamine, an irreversible antagonist, has been used with some success. Detrusor atony in dogs Bethanechol is the molecule most frequently used for the treatment of bladder atony. The dosage for dogs is 5–25 mg/dog, PO, tid, and for cats is 2.5–7.5 mg/cat, PO, tid. A recent retrospective study has shown success with testosterone cypionate in male dogs with USMI but had a very small sample size. Recent references from PubMed and VetMedResource. The standard treatment for dogs with ureteral ectopia is surgical correction, but postoperative success rates vary between 50-75%. Response to treatment is variable in male dogs, with one study showing a response rate of only 43% in male dogs treated with phenylpropanolamine, versus the reported 75-90% in females. This results in alteration of the normal flow and rising of the bladder pressure. Detrusor atony of the urinar dystocia in a dog bladder following prolonge 2 A FIVE-year-old full term beagle was presented in dystocia, necessitating a caesarean section. These dogs responded favourably. Cholinergic drugs such as bethanechol are used in animals with detrusor atony.

Eleven dogs were treated with prazosin alone and one with valium alone. All dogs received the alpha-sympatholytic agent prazosin as an initial treatment and in 11 it remained the only therapy. Detrusor sphincter dyssynergia (DSD) is a disturbance of the normal synergistic coordination between bladder contraction and external urethral sphincter muscles relaxation during voiding. 16 From the urodynamic studies 34.9% of those women were classified with detrusor underactivity, 14.0% with detrusor overactivity, 12.8% with bladder outlet obstruction, and 38.4% with normal detrusor function. All dogs received the alpha-sympatholytic agent prazosin as an initial treatment and in 11 it remained the only therapy. 2010, Acquired urinary incontinence in the bitch: Update and perspectives from human medicine. 5. In patients with neurogenic bladder, the urethral sphincter muscle contracts during voiding instead of completely relaxing. Lee et al investigated the urodynamic characteristics and bladder sensory function in 86 consecutive women with type 2 diabetes who had not sought treatment for DBD.

There was a good effect in seven and a moderate response in the other four dogs. This document reviews the following topics related to IDC/atonic bladder: 1) the lack of standardized terminology, 2) causes and medical consequences and 3) current treatment options and their limitations.